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Hydromorphone is primarily used to relieve moderate to severe pain that cannot be adequately managed with other pain medications or treatments. It is often prescribed for acute pain following surgery or injury, as well as for chronic pain conditions such as cancer-related pain.

Hydromorphone is a full opioid agonist, meaning it binds to and activates opioid receptors in the brain and spinal cord to produce its analgesic effects. It primarily acts on mu-opioid receptors, but it also affects other opioid receptor subtypes.

Hydromorphone is available in various forms, including immediate-release oral tablets, extended-release oral capsules, oral solutions, and injectable formulations. The choice of formulation depends on factors such as the severity of pain, the individual's response to treatment, and the need for sustained pain relief.