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Methadone is a versatile medication with several important uses, primarily centered around managing opioid dependence and chronic pain.

The most well-known application of methadone is the treatment of opioid dependence, especially in those with heroin or other opioid addiction. Long-term methadone administration is used in methadone maintenance therapy (MMT) to stabilize the lives of people battling opioid addiction. Methadone helps patients function normally and participate in other treatment aspects, such as counseling and behavioral therapy, by easing withdrawal symptoms and decreasing cravings.